Odontogenic keratocysts okcs are developmental cysts which occur typically in the jawbones. Nov 10, 2009 the keratocystic odontogenic tumor is a benign developmental tumor with many distinguishing clinical and histologic features. This neoplasia is predominantly found in males and people of white origin. Adenomatoid odontogenic tumors pdf adenomatoid odontogenic tumor aot, a benign hamartomatous lesion of odontogenic origin, is an uncommon tumor which affects mainly. The term odontogenic keratocyst was first used by philipsen in the year 1956. Odontogenic keratocyst of the posterior maxilla report of an. Odontogenic keratocyst is a distinctive form of developmental odontogenic cyst because of its specific histopathologic features, an aggressive biologic behavior and a high recurrence rate. It can occur anywhere in the jaws, but is commonly seen in the posterior part of the mandible. A large extragnathic keratocystic odontogenic tumour.
Presentation of a keratocystic odontogenic tumor with. Case report open access presentation of a keratocystic. Keratocystic odontogenic tumor shows a characteristic potential for infiltrative and aggressive behavior. Keratocystic odontogenic tumor according to lopes et al. S centre for dental studies and research muradnagar. The keratocystic odontogenic tumor is a benign developmental tumor with many distinguishing clinical and histologic features. Surgical management of dentigerous cyst and keratocystic. This is a retrospective study of patients with kcot treated in a single unit over 17 years. Keratocystic odontogenic tumor with an ectopic tooth in. A 14yearold caucasian girl presented for observation of bilateral agenesis. Kcots are regarded as benign aggressive tumors and resection is usually considered as a last option.
Keratocystic odontogenic tumors clinical and molecular features. It most often affects the posterior mandible and most commonly presents in the third decade of life. Treatment options for keratocyst odontogenic tumour kcot. Keratocystic odontogenic tumour an overview sciencedirect. What are synonyms for keratocystic odontogenic tumor. Remnants of dental lamina, and also proliferations of the basal cell layer of oral epithelium, are considered as possible sources of epithelial cells which may proliferate to form a kcot. There were 18 lesions in the posterior mandible, 3 in the anterior mandible and 6 in the posterior maxilla fig.
Benign odontogenic epithelial tumors ameloblastoma squamous odontogenic tumor calcifying epithelial odontogenic tumor adenomatoid odontogenic tumor keratocystic odontogenic tumor odontogenic keratocyst odontogenic epithelial ectomesenchymal ameloblastic. The orthokeratinizing odontogenic cyst is considered an unrelated entity without risk of recurrence or aggressive growth or association with nevoid basal cell carcinoma syndrome. The mouth opening was unlimited, and there was no deviation of the mandible in habitual occlu. Keratocystic odontogenic tumour canadian dental association. Ive gotten a few questions about odontogenic keratocysts lately, so i figured it would be good to write an article detailing what we know about them.
Keratocystic odontogenic tumor with an ectopic tooth in maxilla. To date, various conservative or aggressive management strategies have been. Albodbai mh 21 keratocystic odontogenic tumor in the maxillary sinus. Keratocystic odontogenic tumour who classification of tumours. The lesion occurs over a wide age range with a peak in the second and third decades and demonstrates a predilection for white males 2. Okc is now referred to by the world health organization who as a keratocystic odontogenic tumour kcot, and who defined it as a benign uni or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium. The odontogenic keratocyst okc, first named by philipsen, has recently been renamed by him as the keratocystic odontogenic tumour kcot and reclassified as an odontogenic neoplasm by the world health organization who. Keratocystic odontogenic tumors clinical and molecular. The mandible is more commonly involved than the maxilla 6583% of. Sometimes associated with nevoid basal cell carcinoma syndrome gorlin syndrome. Odontogenic keratocyst okc is a developmental cyst that was first described by philipsen 1956. A keratocystic odontogenic tumor kot formerly known as an odontogenic keratocyst is a benign cystic tumor of dental origin that probably arises from primitive dental lamina, most commonly occurs in the posterior mandible, and almost certainly represents the lesion that used to be known as a primordial cyst.
The differential diagnosis for a multilocular, radiolucent lesion in the body of the mandible is ameloblastoma, keratocystic odontogenic tumor parakeratinizing odontogenic keratocyst, odontogenic myxoma or central giant cell lesion. Keratocystic odontogenic tumor article about keratocystic. Keratocystic odontogenic tumour in a hong kong community. In recent studies a somatic mutation of ptch gene in some. The odontogenic keratocyst, now officially known as the keratocystic odontogenic tumour kcot is an intraosseous tumor. Retrospective analysis of 104 cases of keratocystic odontogenic tumor e539 introduction the odontogenic keratocyst, currently known as kerato cystic odontogenic tumor kcot is a benign cystic lesion of odontogenic origin with a potentially aggressive and infiltrative behavior. In this paper, we shall present one case report of a keratocyst, which derived from an impacted canine. The absence of any information was considered exclusion criteria for the epidemiologic. Features of peripheral keratocystic odontogenic tumor 302 int j clin exp med 2014. Also known as the keratocystic odontic tumor, it is believed to be stemming from the dental lamina. We analyzed the etiopathogenetic, clinical, radiographic, and histopathologic aspects of keratocystic odontogenic tumors, particularly in association with dental anomalies of number, with the aim of providing useful information for their correct diagnosis, treatment, and prognosis within a multidisciplinary approach. The newly acknowledged neoplastic potential and its implications for treatment strategies are also discussed.
Case discussion the most likely diagnosis of this cystic mandibular lesion is either a kcot or a unilocular ameloblastoma. Odontogenic keratocyst symptoms, treatment, pictures. A keratocystic odontogenic tumor is a benign but locally aggressive developmental odontogenic tumor that derives from dental lamina or form their remains and is most commonly located in the mandibular ramus and body. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Okcs have been reclassified under odontogenic tumours in 2005 by the who and have since been termed as keratocystic odontogenic tumours kcots. There are many types of cysts of the jaws, but what makes the odontogenic keratocyst unusual are its characteristic histopathological and clinical features, including potentially aggressive behaviour, high recurrence rate, and an association with the nevoid basal cell carcinoma.
Case report radiological and clinical features of peripheral. A 14yearold caucasian girl presented for observation of bilateral. There are many types of cysts of the jaws, but what makes the odontogenic keratocyst unusual are its characteristic histopathological and clinical features, including potentially aggressive behaviour, high recurrence rate, and an association with the nevoid basal cell carcinoma syndrome. There is a unilocular lytic lesion in the right mandibular angle with imaging appearances of either keratocystic odontogenic tumor or a unilocular ameloblastoma. Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment an overview. Treatment consisted of enucleation and curettage for 22 of the lesions, resection for 2 and marsupialization for 3. Squamous cell carcinoma in a maxillary odontogenic keratocyst. Here we report a case of a recurrent buccal lesion in a 62yearold. It is widely accepted that kcots originate from odontogenic epithelium. Later, who reclassified okc as keratocystic odontogenic tumour kcot and defined it as a benign uni or multicystic, introsseoustumour of. The following data were collected from the case files. The odontogenic keratocyst is a very well known odontogenic cyst. Therefore, in 2005 these lesions were reclassified as keratocystic odontogenic tumors kcots and defined as benign, odontogenic, uni or multicystic intraosseous tumors, with characteristic parakeratinized squamous epithelium lining, having a potential for aggressive and infiltrative growth.
A keratocystic odontogenic tumor is a benign but locally aggressive developmental odontogenic tumor that derives from dental lamina or form their remains and is most commonly located in. Case report keratocystic odontogenic tumor simulating. Synonyms for keratocystic odontogenic tumor in free thesaurus. Keratocystic odontogenic tumor kcot presents most frequently in the second, third and fourth decades of life 54. Keratocystic odontogenic tumor kcot is one of the most common odontogenic tumors of ectodermal origin. Odontogenic keratocyst of the posterior maxilla report of. At that time, it was believed to be a benign, but potentially aggressive and re. Okc is now referred to by the world health organization who as a keratocystic odontogenic tumour kcot, and who defined it as a benign uni or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified. It has the potential for infiltration and local aggressiveness and has a high rate of recurrence.
Keratocystic odontogenic tumors, keratocyst, odontogenic keratocyst, iodine tincture 1. The keratocystic odontogenic tumor is believed to arise from dental lamina and represents between 412% of all odontogenic cysts. In a recent study on keratin profiling in kcots, it was demonstrated that similar keratins 17 and 19 are expressed both in kcots. The keratocystic odontogenic tumor vu research portal vrije. Also distinguished by parakeratinized epithelial lining. Introduction the frequency of odontogenic cysts in children is relatively low. This article reports a case of odontogenic keratoc yst in left mandibular ramus and describes its clinical, radiographical and histopathological findings along with dif ferential diagnosis. Keratocystic odontogenic tumor, benign tumor, surgery, maxilla 1.
It can occur anywhere in the jaws, but is commonly seen in. Surgical treatment of keratocystic odontogenic tumour. Maxillary peripheral keratocystic odontogenic tumor. A keratocyst in the buccal mucosa with the features of. Odontogenic keratocyst of the posterior maxilla report of an unusual case nr figueiredo, ad dinkar, sk satoskar, mm khorate abstract the odontogenic keratocyst is a developmental odontogenic cyst. Keratocystic odontogenic tumour of lesions treated in our clinic. Okc is known for its rapid growth 35 and its tendency to invade the adjacent tissues including bone. Case report open access presentation of a keratocystic odontogenic tumor with agenesis. Keratocystic odontogenic tumor synonyms, keratocystic. Because of its features, the keratocystic odontogenic tumor must have more aggressive treatment, compared with odontogenic cysts, and longterm followup is mandatory. The odontogenic keratocyst okc was first described in 1876 1 and named by phillipsen in 1956. They present more commonly in the posterior mandible of young adults than the maxilla. Table 1 description of keratocystic odontogenic tumours and treatment in a series of 21 patients.
Apr, 2016 odontogenic keratocyst or keratocystic odontogengic tumor. Odontogenic keratocyst okc is classified as a developmental cyst originating from remnants of dental lamina, occurring between second and third decades of life, which affects the mandible at a proportion of 2. Introduction odontogenic keratocyst okc was a neoplasm described by philipsen in 1956 and was confirmed by 1 browne in 1970 and 1971 2 3. Among the pathological entities that affect the maxillofacial region, keratocystic odontogenic tumour has been subject to a lot of debates. We analyzed the etiopathogenetic, clinical, radiographic, and histopathologic aspects of keratocystic. The odontogenic keratocyst can be defined as a cystic benign tumor, being localized at the level of the mandible or the maxilla. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
Keratocystic odontogenic tumor kcot of the mandible. This condition is often encountered in young patients, who are in their 2nd or 3rd decade of life. Keratocystic odontogenic tumor in the maxillary sinus. Recurrence rate of keratocystic odontogenic tumor after conservative. The discovery of increased mitotic activity in the cyst epithelium, the potential for epithelial budding from basal layer or daughter cysts in the cyst. Aug 11, 2009 the odontogenic keratocyst is a very well known odontogenic cyst. The mouth opening was unlimited, and there was no deviation of the mandible in habitual occlusion. Keratocystic odontogenic tumor definition of keratocystic. Feedback controls limit cell division after a certain number of cells have developed, allowing for tissue repair click the link for more information.
There is no clinical consensus for the treatment of keratocystic odontogenic tumor kcot. Keratocystic odontogenic tumor kot represents form 515% of all maxillar cystic lesions. Odontogenic cysts were not considered in the new 2005 classification, which means that the previous 1992 classification is still relevant for cysts of the jaws and maxillofacial region, with one notable exception. Treatment consisted of enucleation and curettage for 22 of the lesions, resection. Keratocystic odontogenic tumor kcot is a benign intraosseous neoplasm of odontogenic origin with high recurrence rate. Even though there are classical clinical features for each of the odontogenic lesions, at times, it may be difficult to arrive at a clinical. The keratocystic odontogenic tumor is a benign odontogenic cystic neoplasia characterized by its thin, squamous epithelium with superficial parakeratosis. Keratocystic odontogenic tumor kcot, formerly known as okc, is a benign unicystic or multicystic intraosseous neoplasm of odontogenic origin which arises from the remnants of the dental lamina both in mandible and maxilla. First described by philipsen in 1956, the odontogenic keratocyst is characterized by a large squamous keratinization of its border, an aggressive growth and a high recurrent rate.
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